These five FERNE clinical summaries provide a comprehensive update on the evaluation and management of emergency department patients with mild traumatic brain injury (mTBI), emphasizing the integration of clinical assessment, neuroimaging, and emerging diagnostic strategies. They examine the clinical role of the blood biomarkers GFAP and UCH-L1, including FDA-cleared applications, diagnostic performance, appropriate patient selection, limitations, confounding […]
Minor TBI/Concussion
Journal Club #3: MILD TBI PATIENT EVALUATION: BRAIN BIOMARKERS TESTING
This FERNE Journal Club addresses the specific issue of how brain biomarker lab testing can be used to enhance the emergency care of mild traumatic brain injury (mTBI) patients. This analysis of the optimal care of mTBI patients with possible concussion includes important clinical concepts regarding the potential use of brain biomarker labs. The discussion of brain […]
Journal Club #2: MILD TBI PATIENT EVALUATION: LAB BIOMARKERS / NEUROIMAGING
This FERNE Journal Club addresses the general issues related to the emergency care of mild traumatic brain injury (mTBI) patients. This analysis of the optimal care of mTBI patients with possible concussion includes important clinical concepts regarding use of the clinical exam, brain biomarkers, and neuroimaging. The discussion of optimal mTBI patient care includes the following: Use […]
Emergencies in Medicine Maui 2025
FERNE Clinical Update MILD TBI BIOMARKERS: CONCLUSIONS AND CLINICAL RECOMMENDATIONS The Clinical Imperative and Core Concepts – CLINICAL IMPERATIVE The primary goal of incorporating blood biomarkers (Glial Fibrillary Acidic Protein [GFAP] and Ubiquitin C-Terminal Hydrolase L1 [UCH-L1]) is to safely reduce unnecessary head Computed Tomography (CT) scans and associated radiation exposure in the majority of […]